Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SOS1 All Species: 21.21
Human Site: S1193 Identified Species: 66.67
UniProt: Q07889 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07889 NP_005624.2 1333 152464 S1193 Q P T S K A Y S P R Y S I S D
Chimpanzee Pan troglodytes XP_515425 1598 179688 S1458 Q P T S K A Y S P R Y S L S D
Rhesus Macaque Macaca mulatta XP_001103238 1312 149667 S1172 Q P T S K A Y S P R Y S I S D
Dog Lupus familis XP_540157 1342 152915 S1202 Q P T S K A Y S P R Y S I S D
Cat Felis silvestris
Mouse Mus musculus Q62245 1319 150865 S1179 Q P T S K A Y S P R Y S I S D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509981 1303 148422 S1164 V F D S D H S S P F H S S S D
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26675 1596 177916 P1383 D G E L S P P P I P P R L N H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782335 1310 150821 S1169 P R H N S Q N S S Q T M N G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.3 95.7 96.8 N.A. 96.6 N.A. N.A. 87.4 N.A. N.A. N.A. N.A. 40.6 N.A. N.A. 50.5
Protein Similarity: 100 83.4 96.3 97.6 N.A. 97.9 N.A. N.A. 90.3 N.A. N.A. N.A. N.A. 56.6 N.A. N.A. 67.7
P-Site Identity: 100 93.3 100 100 N.A. 100 N.A. N.A. 40 N.A. N.A. N.A. N.A. 0 N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 46.6 N.A. N.A. N.A. N.A. 13.3 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 13 0 13 0 13 0 0 0 0 0 0 0 0 0 75 % D
% Glu: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 13 0 0 0 0 0 0 0 13 0 0 0 0 0 % F
% Gly: 0 13 0 0 0 0 0 0 0 0 0 0 0 13 13 % G
% His: 0 0 13 0 0 13 0 0 0 0 13 0 0 0 13 % H
% Ile: 0 0 0 0 0 0 0 0 13 0 0 0 50 0 0 % I
% Lys: 0 0 0 0 63 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 13 0 0 0 0 0 0 0 0 25 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 13 0 0 0 % M
% Asn: 0 0 0 13 0 0 13 0 0 0 0 0 13 13 0 % N
% Pro: 13 63 0 0 0 13 13 13 75 13 13 0 0 0 0 % P
% Gln: 63 0 0 0 0 13 0 0 0 13 0 0 0 0 0 % Q
% Arg: 0 13 0 0 0 0 0 0 0 63 0 13 0 0 0 % R
% Ser: 0 0 0 75 25 0 13 88 13 0 0 75 13 75 0 % S
% Thr: 0 0 63 0 0 0 0 0 0 0 13 0 0 0 0 % T
% Val: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 63 0 0 0 63 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _